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pentobarbital will reduce the extent or outcome of pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the extent or influence of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with solid CYP3A4 inducers just isn't advisedAs